Multivariate batch to batch optimisation of fermentation processes incorporating validity constraints

Optimisation of Operating Conditions in Fed-batch Baker’s Yeast Fermentation

Saccharamyces cerevisia known as baker’s yeast is a product used in various food industries. Worldwide economic competition makes it a necessity that industrial processes be operated in optimum conditions, thus maximisation of biomass in production of saccharamyces cerevisia in fedbatch reactors has gained importance. The facts that the dynamic fermentation model must be considered as a constra...

Batch-to-Batch Iterative Learning Control of a Fed-batch Fermentation Process Using Incrementally Updated Models

Batch-to-batch iterative learning control of a fed-batch fermentation process using batchwise linearised models identified from process operation data is presented in this paper. Due to model-plant mismatches and the present of unknown disturbances, off-line calculated control policy may not be optimal when implemented to the real process. The repetitive nature of batch process allows informati...

The scale-up of microbial batch and fed-batch fermentation processes.

Optimal Adaptive Control of Fed-batch Fermentation Processes

This paper presents a unifying methodology for optimization of biotechnological processes, namely optimal adaptive control, which combines the advantages of both the optimal control and the adaptive control approaches. As an example, the design of a substrate feeding rate controller for a class of biotechnologlcal processes in stirred tank reactors characterized by a decoupling between biomass ...

Intelligent Software Sensors for Fed-Batch Fermentation Processes

Software sensors have attracted great research interests due to the problem of lacking suitable and robust online sensors for key fermentation variables in fed-batch fermentation processes. In this paper, intelligent software sensors have been developed based on multivariate statistical process control methods. The software sensors not only provide real time estimation of key variables but also...